The San Francisco Giants (77-79) are favorites (-198) on the moneyline when they take on the St. Louis Cardinals (76-80) Tuesday at 9:45 p.m. ET, live on NBCS-BA and FDSMW.
Logan Webb will get the ball for San Francisco while St. Louis will counter with Andre Pallante.
Giants vs. Cardinals Odds
Giants odds to win: -198 Cardinals odds to win: +164 Spread: Giants -1.5 Total: 7.5 runsGiants vs. Cardinals Promo Codes
Game Time and Information
Date: Tuesday, September 23, 2025 Time: 9:45 p.m. ET TV: NBCS-BA and FDSMWWho Will Win Giants vs. Cardinals?
Giants and Cardinals Betting Trends
The Giants are 46-41 in games they were favored on the moneyline (winning 52.9% of those games).
In games it has played as moneyline favorites with odds of -198 or shorter, San Francisco has a 6-5 record (winning 54.5% of its games).
The Cardinals have won 42, or 47.7%, of the 88 games they’ve played as underdogs this season.
This season, St. Louis has won two of its nine games, or 22.2%, when it’s the underdog by at least +164 on the moneyline.
In the 156 games in which bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 72 times (72-74-10).
The Cardinals and their opponents have hit the over in 77 of their 155 games with a total this season.
Giants Stats & Insights
The Giants have the No. 17 offense in MLB action scoring 4.3 runs per game (674 total runs).
San Francisco ranks 19th in MLB play with 164 home runs. They average 1.1 per game.
The Giants’ .234 batting average ranks 26th in the majors.
San Francisco strikes out 8.6 times per game to rank 19th in the majors.
The Giants pitching staff ranks 15th in the majors with a collective 8.5 strikeouts per nine innings.
San Francisco has the ninth-ranked team ERA across all MLB pitching staffs (3.85).
Cardinals Stats & Insights
The Cardinals have scored the 18th-most runs in the league this season with 667 (4.3 per game).
St. Louis ranks 28th in Major League Baseball with just 143 home runs as a team.
The Cardinals rank 17th in MLB with a .245 team batting average.
St. Louis is one of the best teams in baseball at making contact this season, ranking ninth with an average of 8.1 strikeouts per game.
The Cardinals average just 8.5 strikeouts per nine innings as a pitching staff, which ranks 29th in the majors.
St. Louis has the 19th-ranked ERA (4.23) in the majors this season.
Giants Key Players to Watch
Webb (14-11 with a 3.27 ERA and 211 strikeouts in 195 2/3 innings pitched) gets the start for the Giants, his 33rd of the season.
Rafael Devers is batting .251 this season with a team-high 32 home runs and 105 RBI.
Jung Hoo Lee leads San Francisco in batting with a .261 average while slugging eight homers and driving in 52 runs.
Willy Adames has 128 hits this season and a slash line of .226/.320/.418.
Heliot Ramos has collected 152 hits this season and has an OBP of .330. He’s slugging .391 on the year.
Cardinals Key Players to Watch
The Cardinals will send Pallante (6-15) to the mound for his 31st start this season.
Alec Burleson leads the Cardinals with a team-high batting average of .289.
Brendan Donovan is hitting .282 with 27 doubles, 10 home runs and 42 walks.
Lars Nootbaar is hitting .236 with 23 doubles, a triple, 13 home runs and 59 walks.
Ivan Herrera has 13 doubles, 17 home runs and 39 walks while batting .281.
Giants and Cardinals Injuries
Giants: Dominic Smith: 10 Day IL (Hamstring), Landen Roupp: 15 Day IL (Knee), Carson Whisenhunt: 15 Day IL (Back), Tom Murphy: 60 Day IL (Back), Randy Rodriguez: 60 Day IL (Elbow), Erik Miller: 60 Day IL (Elbow)
Cardinals: Masyn Winn: 10 Day IL (Meniscus), Willson Contreras: 10 Day IL (Shoulder), Zack Thompson: 60 Day IL (Lat), Brendan Donovan: day-to-day (Undisclosed), Nolan Gorman: day-to-day (Undisclosed)
Giants vs. Cardinals Prediction
Score Prediction: Giants 5, Cardinals 4 Total Prediction: Over 7.5 runsHow to Bet on Giants vs. Cardinals
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