The St. Louis Cardinals (76-80) enter Monday’s matchup with the San Francisco Giants (77-79) following their 2-1 series victory over the Brewers. The Giants, coming off of a series loss against the Dodgers, are listed as -148 favorites for Game 1. The series begins at Oracle Park, starting at 9:45 p.m. ET on NBCS-BA and FDSMW.
San Francisco’s Justin Verlander gets the start, and he’ll go against St. Louis’ Michael McGreevy.
Giants vs. Cardinals Odds
Giants odds to win: -148 Cardinals odds to win: +123 Spread: Giants -1.5 Total: 7.5 runsGiants vs. Cardinals Promo Codes
Game Time and Information
Date: Monday, September 22, 2025 Time: 9:45 p.m. ET TV: NBCS-BA and FDSMWWho Will Win Giants vs. Cardinals?
Giants and Cardinals Betting Trends
The Giants have been favored on the moneyline 87 total times this season. They’ve finished 46-41 in those games.
San Francisco has a 23-21 record (winning 52.3% of its games) when playing as moneyline favorites of -148 or shorter.
The Cardinals have been underdogs in 88 games this season and won 42 (47.7%) of those contests.
This season, St. Louis has won 12 of its 33 games, or 36.4%, when it’s the underdog by at least +123 on the moneyline.
The Giants have played in 156 games with over/under set, and have combined with opponents to go over the total 72 times (72-74-10).
Games involving the Cardinals have gone over the total set by sportsbooks in 77 of 155 chances this season.
Giants Stats & Insights
The Giants are the 17th-highest scoring team in baseball averaging 4.3 runs per game (674 total).
San Francisco is 19th in baseball with 164 total home runs.
The Giants have the fifth-worst batting average in the majors (.234).
San Francisco’s 8.6 strikeouts per game rank 20th in the majors.
The Giants pitching staff is 15th in the majors with a collective 8.5 strikeouts per nine innings.
San Francisco has a 3.85 team ERA that ranks ninth across all MLB pitching staffs.
Cardinals Stats & Insights
The Cardinals have scored 667 runs (4.3 per game) this season, which ranks 18th in MLB.
St. Louis’ 143 home runs rank 28th in MLB this season.
The Cardinals’ .245 batting average ranks 17th in the league this season.
St. Louis is one of the best teams in baseball at making contact this season, ranking ninth with an average of 8.1 strikeouts per game.
The Cardinals have a 7.6 K/9 this season as a pitching staff, which ranks 29th in baseball.
St. Louis has pitched to a 4.23 ERA this season, which ranks 19th in baseball.
Giants Key Players to Watch
Verlander makes the start for the Giants, his 28th of the season. He is 3-10 with a 3.75 ERA and 127 strikeouts in 141 2/3 innings pitched.
Rafael Devers leads San Francisco in home runs (32) and runs batted in (105) this season while batting .251.
Jung Hoo Lee leads San Francisco in batting with a .261 average while slugging eight homers and driving in 52 runs.
Willy Adames has collected 128 base hits, an OBP of .320 and a slugging percentage of .418 this season.
Matt Chapman has collected 101 hits this season and has an OBP of .342. He’s slugging .433 on the year.
Cardinals Key Players to Watch
The Cardinals will hand the ball to McGreevy (7-3) for his 15th start of the season.
Alec Burleson leads the Cardinals with a team-best batting average of .289.
Brendan Donovan has 27 doubles, 10 home runs and 42 walks while hitting .282.
Lars Nootbaar is batting .236 with 23 doubles, a triple, 13 home runs and 59 walks.
Ivan Herrera is batting .281 with 13 doubles, 17 home runs and 39 walks.
Giants and Cardinals Injuries
Giants: Dominic Smith: 10 Day IL (Hamstring), Landen Roupp: 15 Day IL (Knee), Carson Whisenhunt: 15 Day IL (Back), Tom Murphy: 60 Day IL (Back), Randy Rodriguez: 60 Day IL (Elbow), Erik Miller: 60 Day IL (Elbow)
Cardinals: Masyn Winn: 10 Day IL (Meniscus), Willson Contreras: 10 Day IL (Shoulder), Zack Thompson: 60 Day IL (Lat), Nolan Gorman: day-to-day (Undisclosed)
Giants vs. Cardinals Prediction
Score Prediction: Giants 5, Cardinals 4 Total Prediction: Over 7.5 runsHow to Bet on Giants vs. Cardinals
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