Led by James McCann (two-game homer streak), the Arizona Diamondbacks (76-75) are favorites versus the San Francisco Giants (75-75) Wednesday at 3:40 p.m. ET. Bookmakers have named the Diamondbacks as -129 favorites for the game, which airs on MLB Network, ARID, and NBCS-BA.
Brandon Pfaadt will get the ball for Arizona while San Francisco will counter with Justin Verlander.
Diamondbacks vs. Giants Odds
Diamondbacks odds to win: -129 Giants odds to win: +109 Spread: Diamondbacks -1.5 Total: 9 runsDiamondbacks vs. Giants Promo Codes
Game Time and Information
Date: Wednesday, September 17, 2025 Time: 3:40 p.m. ET TV: MLB Network, ARID, and NBCS-BAWho Will Win Diamondbacks vs. Giants?
Diamondbacks and Giants Betting Trends
The Diamondbacks have won 44 of the 85 games they were the moneyline favorite this season (51.8%).
Arizona has a 27-25 record (winning 51.9% of its games) when playing as moneyline favorites of -129 or shorter.
The Giants have been underdogs in 62 games this season and won 29 (46.8%) of those contests.
This season, San Francisco has won 19 of its 42 games, or 45.2%, when it’s the underdog by at least +109 on the moneyline.
In the 150 games in which bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 72 times (72-69-9).
The Giants’ games have gone over the total in 70 of their 150 chances.
Diamondbacks Stats & Insights
The Diamondbacks score the fifth-most runs in baseball (751 total, five per game).
Arizona is seventh in MLB action with 204 home runs. They average 1.4 per game.
The Diamondbacks are eighth in MLB with a .251 batting average.
Arizona strikes out 8.1 times per game, the 10th-best average in the majors.
The pitching staff for the Diamondbacks has a collective eight K/9, which ranks 22nd in the majors.
Arizona has a 4.45 team ERA that ranks 22nd across all MLB pitching staffs.
Giants Stats & Insights
The Giants have scored the 17th-most runs in the league this season with 652 (4.3 per game).
San Francisco has hit 161 homers this season, which ranks 19th in the majors.
The Giants have a team batting average of just .237 this season, which ranks 26th among MLB teams.
San Francisco ranks 17th with an average of 8.5 strikeouts per game.
The Giants have an 8.6 K/9 this season as a pitching staff, which ranks 12th in the majors.
San Francisco has pitched to a 3.86 ERA this season, which ranks 10th in baseball.
Diamondbacks Key Players to Watch
Pfaadt (13-8) gets the starting nod for the Diamondbacks in his 31st start of the season. He’s put together a 5.31 ERA in 157 2/3 innings pitched, with 131 strikeouts.
Geraldo Perdomo leads Arizona in runs batted in with 97 while batting .290, which is also best on the team.
Corbin Carroll leads Arizona in home runs with 30 while driving in 76 runs and slugging .542.
Ketel Marte has 121 hits this season and a slash line of .277/.376/.501.
Gabriel Moreno has collected 69 hits this season and has an OBP of .347. He’s slugging .456 on the year.
Giants Key Players to Watch
The Giants will send Verlander (3-10) to the mound for his 27th start this season.
Rafael Devers has accumulated a team-high 31 home runs and 102 runs batted in.
Jung Hoo Lee’s .264 batting average leads his team.
Willy Adames is batting .230 with 20 doubles, two triples, 28 home runs and 71 walks.
Matt Chapman is hitting .239 with 20 doubles, two triples, 21 home runs and 66 walks.
Diamondbacks and Giants Injuries
Diamondbacks: Tyler Locklear: 10 Day IL (Elbow), Lourdes Gurriel Jr.: 10 Day IL (Acl), Blake Walston: 60 Day IL (Elbow), Corbin Burnes: 60 Day IL (Elbow), A.J. Puk: 60 Day IL (Elbow), Christian Montes De Oca: 60 Day IL (Elbow), Cristian Mena: 60 Day IL (Shoulder), Justin Martinez: 60 Day IL (Elbow), Kevin Ginkel: 60 Day IL (Shoulder), Pavin Smith: 60 Day IL (Quadricep), Tommy Henry: 60 Day IL (Elbow)
Giants: Dominic Smith: 10 Day IL (Hamstring), Landen Roupp: 15 Day IL (Knee), Carson Whisenhunt: 15 Day IL (Back), Tom Murphy: 60 Day IL (Back), Randy Rodriguez: 60 Day IL (Elbow), Erik Miller: 60 Day IL (Elbow)
Diamondbacks vs. Giants Prediction
Score Prediction: Diamondbacks 6, Giants 5 Total Prediction: Over 9 runsHow to Bet on Diamondbacks vs. Giants
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