Mariners vs. Angels Prediction: Expert Picks, Odds, Stats & Best Bets – Friday, September 12, 2025 ...Middle East

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The Seattle Mariners (78-68) host the Los Angeles Angels (69-77) at 10:10 p.m. ET Friday for a sluggers’ duel between two of the best home-run hitters in baseball. Cal Raleigh has racked up 53 homers this season (No. 1 in the league) for the favored Mariners which sit as -164 favorites, while Jo Adell ranks eighth in the majors with 35 dingers of his own for the underdogs.

Seattle’s Luis Castillo gets the start, and he’ll go against Los Angeles’ Yusei Kikuchi.

Mariners vs. Angels Odds

Mariners odds to win: -164 Angels odds to win: +139 Spread: Mariners -1.5 Total: 7.5 runs

Mariners vs. Angels Promo Codes

Game Time and Information

Date: Friday, September 12, 2025 Time: 10:10 p.m. ET TV: Apple TV+

Who Will Win Mariners vs. Angels?

Mariners and Angels Betting Trends

The Mariners have gone 56-45 in games they were favored on the moneyline (winning 55.4% of those games).

When it has played as moneyline favorites with odds of -164 or shorter, Seattle has a record of 21-10 (67.7%).

The Angels have been underdogs in 109 games this season and won 51 (46.8%) of those contests.

Los Angeles has a record of 24-21, a 53.3% win rate, when it’s set as an underdog of +139 or more by bookmakers this season.

The Mariners have played in 146 games with an over/under set, and have combined with their opponents to go over the total 78 times (78-63-5).

The Angels and their opponents have hit the over in 77 of their 146 games with a total this season.

Mariners Stats & Insights

The Mariners have the No. 11 offense in MLB action scoring 4.7 runs per game (680 total runs).

Seattle ranks third in baseball with 213 home runs. They average 1.5 per game.

The Mariners’ .243 batting average ranks 19th in the majors.

Seattle’s hitters strike out 8.9 times per game, the 26th-most in baseball.

The pitching staff for the Mariners has a collective 8.6 K/9, which ranks 11th in the majors.

Seattle has the 15th-ranked team ERA among all MLB pitching staffs (3.97).

Angels Stats & Insights

The Angels have scored the 21st-most runs in the league this season with 627 (4.3 per game).

Los Angeles’ 201 home runs rank fourth in Major League Baseball.

The Angels rank 29th in MLB with a team batting average of just .229.

Los Angeles is a team with a lot of swing and miss this season, ranking last with an average of 9.8 strikeouts per game.

The Angels average the 22nd-most strikeouts per nine innings (eight) in the majors this season.

Los Angeles has the 27th-ranked ERA (4.81) in the majors this season.

Mariners Key Players to Watch

Castillo (9-8 with a 3.85 ERA and 144 strikeouts in 161 1/3 innings pitched) aims for his 10th win when he makes the start for the Mariners, his 30th of the season.

Raleigh leads Seattle in home runs (53) and runs batted in (113) this season while batting .241.

Julio Rodriguez is batting .265 with an OBP of .316 and a slugging percentage of .472 this season.

Josh Naylor is batting .285 to lead Seattle, while adding 19 homers and 80 runs batted in this season.

Eugenio Suarez is batting .233 with an OBP of .306 and a slugging percentage of .539 this season.

Angels Key Players to Watch

The Angels will send Kikuchi (6-11) to the mound for his 31st start this season.

Taylor Ward paces the Angels with 96 runs batted in.

Zach Neto has 29 doubles, a triple, 26 home runs and 32 walks while hitting .257.

Adell leads the Angels with 35 home runs.

Mike Trout has 13 doubles, a triple, 20 home runs and 83 walks while hitting .234.

Mariners and Angels Injuries

Mariners: Jackson Kowar: 15 Day IL (Shoulder), Logan Evans: 15 Day IL (Elbow), Gregory Santos: 60 Day IL (Knee), Ryan Bliss: 60 Day IL (Biceps), Trent Thornton: 60 Day IL (Achilles)

Angels: Nolan Schanuel: 10 Day IL (Wrist), Tyler Anderson: 15 Day IL (Oblique), Ryan Zeferjahn: 15 Day IL (Knee), Reid Detmers: 15 Day IL (Elbow), Anthony Rendón: 60 Day IL (Hip), Gustavo Campero: 60 Day IL (Ankle), Jorge Soler: 60 Day IL (Back), Ben Joyce: 60 Day IL (Shoulder), Carson Fulmer: 60 Day IL (Elbow), Hunter Strickland: 60 Day IL (Shoulder), Victor Mederos: 60 Day IL (Shoulder), Logan O’Hoppe: 7 Day IL (Concussion), Jo Adell: day-to-day (Vertigo)

Mariners vs. Angels Prediction

Score Prediction: Mariners 5, Angels 4 Total Prediction: Over 7.5 runs

How to Bet on Mariners vs. Angels

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