The San Diego Padres (78-65) are favorites (-154) on the moneyline when they square off against the Cincinnati Reds (72-71) Monday at 9:40 p.m. ET, live on SDPA and FDSOH.
San Diego’s Yu Darvish gets the start, and he’ll go against Cincinnati’s Nick Lodolo.
Padres vs. Reds Odds
Padres odds to win: -154 Reds odds to win: +130 Spread: Padres -1.5 Total: 7.5 runsPadres vs. Reds Promo Codes
Game Time and Information
Date: Monday, September 8, 2025 Time: 9:40 p.m. ET TV: SDPA and FDSOHWho Will Win Padres vs. Reds?
Padres and Reds Betting Trends
The Padres are 46-32 in games they were favored on the moneyline (winning 59% of those games).
San Diego has a 22-15 record (winning 59.5% of its games) when it has played as moneyline favorites of -154 or shorter.
This season, the Reds have won 37 out of the 77 games, or 48.1%, in which they’ve been the underdog.
Cincinnati has a record of 13-13 in games where bookmakers have it as underdogs of at least +130 on the moneyline.
The Padres have combined with opponents to go over the total 61 times this season for a 61-76-6 record against the over/under.
The Reds and their opponents have hit the over in 54 of their 140 games with a total this season.
Padres Stats & Insights
The Padres have the No. 21 offense in MLB play scoring 4.3 runs per game (610 total runs).
San Diego has hit the second-fewest home runs in baseball this season (127).
The Padres’ .253 batting average is sixth-best in MLB.
San Diego’s hitters strike out 7.1 times per game, the third-fewest strikeouts in baseball.
The 8.8 strikeouts per nine innings put together by the Padres pitching staff ranks eighth in MLB.
San Diego has a 3.67 team ERA that ranks fourth across all MLB pitching staffs.
Reds Stats & Insights
The Reds have scored 647 runs (4.5 per game) this season, which ranks 13th in MLB.
Cincinnati has hit 141 homers this season, which ranks 24th in the majors.
The Reds rank 16th in MLB with a .248 team batting average.
Cincinnati ranks 22nd in strikeouts per game (8.7) among MLB offenses.
The Reds strike out 8.7 batters per nine innings as a pitching staff, 10th-best in MLB.
Cincinnati pitchers have a combined ERA of 3.94 ERA this year, which ranks 16th in MLB.
Padres Key Players to Watch
Darvish gets the start for the Padres, his 12th of the season. He is 3-5 with a 5.75 ERA and 48 strikeouts in 51 2/3 innings pitched.
Fernando Tatis Jr. has been key for San Diego with 140 hits, an OBP of .367 plus a slugging percentage of .433.
Manny Machado is batting .280 this season with a team-high 23 home runs and 84 RBI.
Luis Arraez is batting .285 to lead San Diego, while adding seven homers and 54 runs batted in this season.
Ramon Laureano leads San Diego in home runs with 23 while driving in 71 runs and slugging .548.
Reds Key Players to Watch
The Reds will hand the ball to Lodolo (8-7) for his 25th start of the season.
Elly De La Cruz paces the Reds in home runs (19) and runs batted in (80).
TJ Friedl has 20 doubles, two triples, 11 home runs and 70 walks while batting .265.
Spencer Steer is hitting .239 with 20 doubles, two triples, 17 home runs and 45 walks.
Austin Hays is batting .263 with 15 doubles, five triples, 14 home runs and 27 walks.
Padres and Reds Injuries
Padres: Xander Bogaerts: 10 Day IL (Foot), Nestor Cortes: 15 Day IL (Elbow), Michael King: 15 Day IL (Knee), Jason Adam: 15 Day IL (Quadricep), Jhony Brito: 60 Day IL (Forearm), Joe Musgrove: 60 Day IL (Elbow)
Reds: Graham Ashcraft: 15 Day IL (Forearm), Chase Burns: 15 Day IL (Elbow), Tyler Callihan: 60 Day IL (Forearm), Carson Spiers: 60 Day IL (Shoulder), Wade Miley: 60 Day IL (Flexor), Julian Aguiar: 60 Day IL (Elbow), Brandon Williamson: 60 Day IL (Elbow), Ian Gibaut: 60 Day IL (Shoulder), Rhett Lowder: 60 Day IL (Forearm)
Padres vs. Reds Prediction
Score Prediction: Padres 5, Reds 4 Total Prediction: Over 7.5 runsHow to Bet on Padres vs. Reds
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