The San Francisco Giants (71-69) are the underdogs on the moneyline (-101) in Saturday’s contest with the St. Louis Cardinals (70-71). Game time is set for 7:15 p.m. ET on FOX. The Giants are favored against the spread in this one (1.5) with +160 odds.
St. Louis’ Andre Pallante and San Francisco’s Justin Verlander have been named the starters for this contest.
Cardinals vs. Giants Odds
Cardinals odds to win: -119 Giants odds to win: -101 Spread: Giants -1.5 Total: 8.5 runsCardinals vs. Giants Promo Codes
Game Time and Information
Date: Saturday, September 6, 2025 Time: 7:15 p.m. ET TV: FOXWho Will Win Cardinals vs. Giants?
Cardinals and Giants Betting Trends
The Cardinals have been the moneyline favorite 64 total times this season. They’ve finished 33-31 in those games.
St. Louis has gone 28-22 (winning 56% of its games) when playing as moneyline favorites of -119 or shorter.
The Giants have entered the game as underdogs 57 times this season and won 27, or 47.4%, of those games.
San Francisco has entered 45 games this season as the underdog by -101 or more and is 22-23 in those contests.
The Cardinals have had an over/under set by oddsmakers 140 times, and have combined with opponents to go over the total in 71 of those games (71-62-7).
The Giants and their opponents have hit the over in 65 of their 140 games with a total this season.
Cardinals Stats & Insights
The Cardinals are the 16th-highest scoring team in MLB play averaging 4.3 runs per game (613 total).
St. Louis is fifth-worst in MLB action with 135 home runs.
The Cardinals rank 17th in the majors with a .247 batting average.
St. Louis strikes out eight times per game to rank ninth in baseball.
The pitching staff for the Cardinals has a collective 7.5 K/9, the second-worst in the majors.
St. Louis has the 20th-ranked team ERA among all MLB pitching staffs (4.27).
Giants Stats & Insights
The Giants rank 20th in the majors with 605 total runs scored this season.
San Francisco ranks 20th in Major League Baseball with 150 home runs.
The Giants rank 25th in MLB with a .238 team batting average.
San Francisco ranks 18th in strikeouts per game (8.5) among MLB offenses.
The Giants average the 11th-most strikeouts per nine innings (8.6) in the majors this season.
San Francisco has pitched to a 3.78 ERA this season, which ranks sixth in baseball.
Cardinals Key Players to Watch
The Cardinals will send Pallante (6-13) out for his 28th start of the season. He is 6-13 with a 5.37 ERA and 101 strikeouts through 144 2/3 innings pitched.
Masyn Winn is batting .255 with nine home runs and 51 RBI for St. Louis this season.
Lars Nootbaar has 106 hits and an OBP of .332 to go with a slugging percentage of .387 this season.
Ivan Herrera has 88 hits this season and a slash line of .284/.367/.445.
Victor Scott II is batting .223 with an OBP of .311 and a slugging percentage of .311 this season.
Giants Key Players to Watch
The Giants’ Verlander (3-10) will make his 25th start of the season.
Rafael Devers has accumulated a team-best 30 home runs and 97 runs batted in.
Jung Hoo Lee is hitting .262 with 30 doubles, 10 triples, seven home runs and 44 walks.
Willy Adames has 18 doubles, two triples, 26 home runs and 66 walks while hitting .230.
Heliot Ramos has a club-leading .268 batting average.
Cardinals and Giants Injuries
Cardinals: Alec Burleson: 10 Day IL (Wrist), Nolan Arenado: 10 Day IL (Shoulder), Brendan Donovan: 10 Day IL (Groin), John King: 15 Day IL (Back), Zack Thompson: 60 Day IL (Lat)
Giants: Jerar Encarnación: 10 Day IL (Hamstring), Landen Roupp: 15 Day IL (Knee), Carson Whisenhunt: 15 Day IL (Back), Tom Murphy: 60 Day IL (Back), Randy Rodriguez: 60 Day IL (Elbow), Erik Miller: 60 Day IL (Elbow)
Cardinals vs. Giants Prediction
Score Prediction: Cardinals 5, Giants 4 Total Prediction: Over 8.5 runsHow to Bet on Cardinals vs. Giants
Get more MLB picks. If you are new to sports betting, read our in-depth guide on betting on Baseball and find the best MLB betting sites and promo codes.
Hence then, the article about cardinals vs giants prediction expert picks odds stats best bets saturday september 6 2025 was published today ( ) and is available on Bleacher Nation ( Middle East ) The editorial team at PressBee has edited and verified it, and it may have been modified, fully republished, or quoted. You can read and follow the updates of this news or article from its original source.
Read More Details
Finally We wish PressBee provided you with enough information of ( Cardinals vs. Giants Prediction: Expert Picks, Odds, Stats & Best Bets – Saturday, September 6, 2025 )
Also on site :