The St. Louis Cardinals (65-68), led by Alec Burleson, host Bryan Reynolds and the Pittsburgh Pirates (58-75) on Wednesday at 7:45 p.m. ET.
See how to watch the St. Louis-Pittsburgh matchup below.
When is Cardinals vs. Pirates and when does it start?
This matchup between the Cardinals and Pirates will take place on Wednesday, August 27, 2025. You should expect the opening pitch at 7:45 p.m. ET.
Where to watch Cardinals vs. Pirates
The Cardinals and Pirates will hit the diamond at Busch Stadium for this matchup on Aug. 27, and if you want to see the event live, get your tickets now from Vivid Seats!
What channel is the game on?
You can catch this game live on Fox Sports 1, FDSMW, SportsNet PT.
Watch the Cardinals vs. Pirates live stream on Fubo
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Cardinals vs. Pirates Game Preview
The Pirates defeated the Cardinals 8-3 yesterday, with Mitch Keller getting the win (6.0 IP, 3 R, 3 H, 9 K) and Henry Davis leading the way offensively (going 1 for 4 with a home run and two RBIs). Andre Pallante (5.0 IP, 7 R, 8 H, 3 K) took the loss for the Cardinals.
Cardinals Stats, Odds & Insights
The Cardinals have a 31-29 record in games they were listed as the moneyline favorite (winning 51.7% of those games).
St. Louis has hit the fifth-fewest home runs in MLB action this season (126).
The Cardinals’ .384 slugging percentage is 25th in baseball.
St. Louis has the 21st-ranked team ERA across all MLB pitching staffs (4.33).
The Cardinals have the 20th-ranked WHIP in the majors (1.308).
Pirates Stats, Odds & Insights
The Pirates have been underdogs in 91 games this season and won 37 (40.7%) of those contests.
Pittsburgh has hit just 97 homers this season, which ranks last in the majors.
The Pirates rank last in the majors with a .353 team slugging percentage.
Pittsburgh has the 14th-ranked ERA (3.96) in the majors this season.
The Pirates have a combined 1.218 WHIP as a pitching staff, fifth-lowest in MLB.
Cardinals Starter Recent Performance: Sonny Gray
Opponent Date IP H R ER K BB at Rays Aug. 21 5.0 6 3 3 6 1 vs. Yankees Aug. 16 5.0 9 6 6 7 2 vs. Cubs Aug. 10 7.0 5 2 1 7 1 at Dodgers Aug. 4 7.0 1 1 1 8 1 vs. Marlins July 29 5.0 8 3 3 5 1Pirates Starter Recent Performance: Carmen Mlodzinski
Opponent Date IP H R ER K BB vs. Rockies Aug. 23 2.0 0 0 0 5 0 at Cubs Aug. 17 4.0 1 1 0 3 0 at Brewers Aug. 13 2.0 1 2 2 2 2 vs. Reds Aug. 9 3.0 3 1 1 3 0 vs. Giants Aug. 6 1.2 0 0 0 1 0Cardinals Key Players to Watch
The Cardinals will send Sonny Gray (12-6) out to make his 27th start of the season. He is 12-6 with a 4.33 ERA and 161 strikeouts in 145 1/3 innings pitched.
In his last time out on Thursday against the Tampa Bay Rays, the righty went five innings, allowing three earned runs while surrendering six hits.
In 26 games this season, the 35-year-old has a 4.33 ERA and 10 strikeouts per nine innings, while allowing a batting average of .263 to his opponents.
Burleson leads St. Louis with a .291 batting average. He’s also hit 16 homers and has 60 RBI.
Willson Contreras is batting .259 this season with a team-high 19 home runs and 73 RBI.
Masyn Winn has collected 116 base hits, an OBP of .310 and a slugging percentage of .372 this season.
Pirates Key Players to Watch
Carmen Mlodzinski (3-7) will take to the mound for the Pirates and make his 11th start of the season.
The right-hander last pitched out of the bullpen on Saturday, when he threw two scoreless innings without allowing a hit to the Colorado Rockies.
The 26-year-old has an ERA of 3.89 and 7.8 strikeouts per nine innings with an opponent batting average of .266 in 26 games this season.
Reynolds has sent home a team-best 66 runs batted in.
Oneil Cruz has shown off his power as he paces his team with 18 home runs.
Andrew McCutchen has 19 doubles, 12 home runs and 54 walks while hitting .241.
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