The Chicago Cubs (76-55) will vie for their fourth straight victory when they visit the San Francisco Giants (63-68) on Wednesday at 9:45 p.m. ET on NBCS-BA and MARQ. The Cubs are listed as -125 favorites by bookmakers, while the Giants are +105 underdogs.
Chicago’s Colin Rea and San Francisco’s Carson Whisenhunt have been named the starters for this contest.
Cubs vs. Giants Odds
Cubs odds to win: -125 Giants odds to win: +105 Spread: Cubs -1.5 Total: 8.5 runsCubs vs. Giants Promo Codes
Game Time and Information
Date: Wednesday, August 27, 2025 Time: 9:45 p.m. ET TV: NBCS-BA and MARQWho Will Win Cubs vs. Giants?
Cubs and Giants Betting Trends
The Cubs have won 64.5% of the games this season when they were favored on the moneyline (60-33).
When it has played as moneyline favorites with odds of -125 or shorter, Chicago has a record of 51-25 (67.1%).
The Giants have been underdogs in 54 games this season and won 25 (46.3%) of those contests.
San Francisco is 17-21 this season when entering a game as the underdog by +105 or more on the moneyline.
The Cubs have played in 131 games with over/under set, and have combined with opponents to go over the total 61 times (61-64-6).
The Giants and their opponents have hit the over in 59 of their 131 games with a total this season.
Cubs Stats & Insights
The Cubs score the seventh-most runs in baseball (648 total, 4.9 per game).
Chicago ranks seventh in baseball with 178 home runs. They average 1.4 per game.
The Cubs are 13th in the majors with a .249 batting average.
Chicago’s batters strike out 7.7 times per game, the fourth-fewest strikeouts in baseball.
The pitching staff for the Cubs has a collective 7.8 K/9, the fourth-worst in MLB.
Chicago has a 3.76 team ERA that ranks seventh across all MLB pitching staffs.
Giants Stats & Insights
The Giants have scored the 25th-most runs in the league this season with 530 (four per game).
San Francisco has hit 128 homers this season, which ranks 23rd in the majors.
The Giants have a team batting average of just .231 this season, which ranks 28th among MLB teams.
San Francisco ranks 19th in strikeouts per game (8.6) among MLB offenses.
The Giants average the 15th-most strikeouts per nine innings (8.5) in the majors this season.
San Francisco pitchers have a combined ERA of 3.74 ERA this year, sixth-best in baseball.
Cubs Key Players to Watch
The Cubs will send Rea (10-5) to the mound for his 23rd start of the season. He is 10-5 with a 3.96 ERA and 93 strikeouts in 127 1/3 innings pitched.
Kyle Tucker is batting .262 with 21 home runs and 69 RBI for Chicago this season.
Pete Crow-Armstrong leads Chicago in home runs with 28 while driving in 82 runs and slugging .508.
Nico Hoerner leads Chicago with a .291 batting average while slugging four homers and driving in 50 runs.
Seiya Suzuki is a key run producer for Chicago with a .243 average, 27 homers and 87 RBI.
Giants Key Players to Watch
The Giants will hand the ball to Whisenhunt (1-1) for his fifth start of the season.
Rafael Devers has a team-best 25 home runs and 83 runs batted in.
Jung Hoo Lee is batting .259 with 29 doubles, 10 triples, seven home runs and 41 walks.
Willy Adames has 18 doubles, two triples, 22 home runs and 63 walks while hitting .225.
Heliot Ramos is hitting .260 to pace his team.
Cubs and Giants Injuries
Cubs: Miguel Amaya: 10 Day IL (Ankle), Ryan Brasier: 15 Day IL (Groin), Mike Soroka: 15 Day IL (Shoulder), Justin Steele: 60 Day IL (Elbow), Eli Morgan: 60 Day IL (Elbow)
Giants: Jerar Encarnación: 10 Day IL (Hamstring), Landen Roupp: 15 Day IL (Knee), Randy Rodriguez: 15 Day IL (Elbow), Tom Murphy: 60 Day IL (Back), Erik Miller: 60 Day IL (Elbow)
Cubs vs. Giants Prediction
Score Prediction: Cubs 5, Giants 4 Total Prediction: Over 8.5 runsHow to Bet on Cubs vs. Giants
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