The Cleveland Guardians (64-60) are the underdogs on the moneyline (+100) in Wednesday’s contest versus the Arizona Diamondbacks (60-66). First pitch is at 3:40 p.m. ET on ARID and CLEG. The Guardians are favored against the spread in this one (1.5) with +160 odds.
Brandon Pfaadt will get the ball for Arizona while Cleveland will counter with Parker Messick.
Diamondbacks vs. Guardians Odds
Diamondbacks odds to win: -120 Guardians odds to win: +100 Spread: Guardians -1.5 Total: 8.5 runsDiamondbacks vs. Guardians Promo Codes
Game Time and Information
Date: Wednesday, August 20, 2025 Time: 3:40 p.m. ET TV: ARID and CLEGWho Will Win Diamondbacks vs. Guardians?
Diamondbacks and Guardians Betting Trends
The Diamondbacks have won 38 of the 76 games they were the moneyline favorite this season (50%).
When it has played as moneyline favorites with odds of -120 or shorter, Arizona has gone 28-31 (47.5%).
This season, the Guardians have won 30 out of the 66 games, or 45.5%, in which they’ve been the underdog.
Cleveland has a record of 23-29 in games where bookmakers have it as underdogs of at least +100 on the moneyline.
In the 125 games in which bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 59 times (59-59-7).
The Guardians’ games have gone over the total in 54 of their 122 chances.
Diamondbacks Stats & Insights
The Diamondbacks have the No. 7 offense in MLB action scoring 4.9 runs per game (619 total runs).
Arizona averages 1.4 home runs per game to rank fourth in baseball with 176 total home runs.
The Diamondbacks are ninth in the majors with a .250 batting average.
Arizona’s batters strike out 7.9 times per game, the ninth-lowest average in the majors.
The 8.1 strikeouts per nine innings put together by the Diamondbacks pitching staff ranks 21st in MLB.
Arizona’s 4.57 team ERA ranks 25th across all MLB pitching staffs.
Guardians Stats & Insights
The Guardians are among the lowest scoring teams in the league, ranking 26th with just 491 total runs (four per game) this season.
Cleveland’s 131 home runs rank 20th in Major League Baseball.
The Guardians have a team batting average of just .227 this season, which ranks last among MLB teams.
Cleveland ranks 12th in strikeouts per game (8.2) among MLB offenses.
The Guardians have an 8.5 K/9 this season as a pitching staff, which ranks 14th in the majors.
Cleveland has pitched to a 3.86 ERA this season, which ranks 12th in baseball.
Diamondbacks Key Players to Watch
Pfaadt (12-8) gets the starting nod for the Diamondbacks in his 26th start of the season. He has a 5.01 ERA in 133 2/3 innings pitched, with 108 strikeouts.
Geraldo Perdomo leads Arizona in runs batted in with 80 and has a batting average of .287.
Corbin Carroll’s 27 home runs are most among Arizona batters. He’s driven in 64 runs this season while slugging .550.
Ketel Marte is batting .295 to lead Arizona, while adding 23 homers and 56 runs batted in this season.
Lourdes Gurriel Jr. has 112 hits and an OBP of .296 to go with a slugging percentage of .412 this season.
Guardians Key Players to Watch
Messick gets the nod for the Guardians and will make his first start of the season.
Jose Ramirez paces the Guardians with 25 home runs and 64 runs batted in, while racking up a team-high batting average of .290.
Steven Kwan has 22 doubles, a triple, 10 home runs and 42 walks while hitting .280.
Carlos Santana is batting .227 with nine doubles, 11 home runs and 52 walks.
Kyle Manzardo is hitting .236 with 14 doubles, two triples, 21 home runs and 40 walks.
Diamondbacks and Guardians Injuries
Diamondbacks: Ryan Thompson: 15 Day IL (Scapular strain), Anthony DeSclafani: 15 Day IL (Thumb), Blake Walston: 60 Day IL (Elbow), Corbin Burnes: 60 Day IL (Elbow), Gabriel Moreno: 60 Day IL (Hand), A.J. Puk: 60 Day IL (Elbow), Christian Montes De Oca: 60 Day IL (Elbow), Cristian Mena: 60 Day IL (Shoulder), Justin Martinez: 60 Day IL (Elbow), Kevin Ginkel: 60 Day IL (Shoulder), Tommy Henry: 60 Day IL (Elbow)
Guardians: Lane Thomas: 10 Day IL (Foot), Ben Lively: 60 Day IL (Forearm), John Means: 60 Day IL (Elbow), Andrew Walters: 60 Day IL (Lat), Will Brennan: 60 Day IL (Forearm), Sam Hentges: 60 Day IL (Shoulder)
Diamondbacks vs. Guardians Prediction
Score Prediction: Diamondbacks 6, Guardians 5 Total Prediction: Over 8.5 runsHow to Bet on Diamondbacks vs. Guardians
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