The Arizona Diamondbacks (54-59) roll into Wednesday’s matchup with the San Diego Padres (62-51) looking to extend a three-game winning streak. The contest starts at 9:40 p.m. ET on MLB Network, ARID, and SDPA with the Padres listed as -145 favorites on the moneyline to stop the Diamondbacks’ streak.
San Diego’s Nestor Cortes gets the start, and he’ll go against Arizona’s Anthony DeSclafani.
Padres vs. Diamondbacks Odds
Padres odds to win: -145 Diamondbacks odds to win: +121 Spread: Padres -1.5 Total: 9.5 runsPadres vs. Diamondbacks Promo Codes
Game Time and Information
Date: Wednesday, August 6, 2025 Time: 9:40 p.m. ET TV: MLB Network, ARID, and SDPAWho Will Win Padres vs. Diamondbacks?
Padres and Diamondbacks Betting Trends
The Padres have won 35 of the 60 games they were listed as the moneyline favorite this season (58.3%).
San Diego has a 20-14 record (winning 58.8% of its games) when playing as moneyline favorites of -145 or shorter.
The Diamondbacks have entered the game as underdogs 44 times this season and won 20, or 45.5%, of those games.
Arizona is 11-5 this season when entering a game as the underdog by +121 or more on the moneyline.
The Padres have combined with opponents to go over the total 45 times this season for a 45-63-5 record against the over/under.
So far this season, the Diamondbacks and their opponents have hit the over in 53 of their 112 games with a total.
Padres Stats & Insights
The Padres have the No. 24 offense in baseball scoring 4.1 runs per game (463 total runs).
San Diego is second-worst in MLB play with 95 home runs.
The Padres have the 13th-ranked batting average in the majors (.250).
San Diego’s batters strike out seven times per game, the third-lowest average in baseball.
The 8.7 strikeouts per nine innings compiled by the Padres pitching staff ranks seventh in MLB.
San Diego has the third-ranked team ERA among all MLB pitching staffs (3.61).
Diamondbacks Stats & Insights
The Diamondbacks have scored 548 runs this season, which ranks seventh in MLB.
Arizona ranks seventh in Major League Baseball with 155 home runs.
The Diamondbacks have a team batting average of .250 this season, which ranks 13th among MLB teams.
Arizona ranks ninth in MLB in strikeouts per game with an average of 7.8 Ks per contest.
The Diamondbacks strike out 8.3 batters per nine innings as a pitching staff, 18th in MLB.
Arizona has the 25th-ranked ERA (4.55) in the majors this season.
Padres Key Players to Watch
The Padres will look to Cortes (1-1) in his third start of the season.
Manny Machado is batting .299 with 20 home runs and 72 RBI. All three of those stats are best among San Diego hitters this season.
Fernando Tatis Jr. has collected 111 hits this season and has an OBP of .367. He’s slugging .440 on the year.
Luis Arraez is slashing .296/.332/.404 this season for the Padres.
Xander Bogaerts is batting .267 with an OBP of .336 and a slugging percentage of .379 this season.
Diamondbacks Key Players to Watch
The Diamondbacks will send DeSclafani to the mound for his third start of the season.
Geraldo Perdomo paces the Diamondbacks with 75 runs batted in.
Corbin Carroll has hit 22 home runs to pace his team.
Ketel Marte leads the Diamondbacks with a .291 batting average.
Lourdes Gurriel Jr. is batting .247 with 21 doubles, two triples, 12 home runs and 26 walks.
Padres and Diamondbacks Injuries
Padres: Jhony Brito: 60 Day IL (Forearm), Michael King: 60 Day IL (Shoulder), Joe Musgrove: 60 Day IL (Elbow)
Diamondbacks: Ildemaro Vargas: 10 Day IL (Foot), Pavin Smith: 10 Day IL (Oblique), Ryan Thompson: 15 Day IL (Scapular strain), Kevin Ginkel: 15 Day IL (Shoulder), Blake Walston: 60 Day IL (Elbow), Corbin Burnes: 60 Day IL (Elbow), Gabriel Moreno: 60 Day IL (Hand), A.J. Puk: 60 Day IL (Elbow), Christian Montes De Oca: 60 Day IL (Elbow), Cristian Mena: 60 Day IL (Shoulder), Justin Martinez: 60 Day IL (Elbow), Tommy Henry: 60 Day IL (Elbow)
Padres vs. Diamondbacks Prediction
Score Prediction: Diamondbacks 5, Padres 4 Total Prediction: Under 9.5 runsHow to Bet on Padres vs. Diamondbacks
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