The remarks came hours after a dramatic attack on an Iranian state TV building, which forced a presenter to flee mid-broadcast and prompted a threat of retaliation against Israeli news channels.
The sudden flare-up has sparked fears of a wider conflict, with US President Donald Trump urging Iran back to the negotiating table after Israel’s attacks derailed ongoing nuclear talks.
Israel’s strikes have killed at least 224 people, including top military commanders, nuclear scientists and civilians, according to Iranian authorities.
“We are changing the face of the Middle East, and that can lead to radical changes inside Iran itself,“ he said.
Inhabitants of Tel Aviv were briefly told to seek shelter early Tuesday, a day after Iranian strikes on multiple Israeli cities pushed the death toll above two dozen in Israel.
Earlier, the live feed of Islamic Republic of Iran Broadcasting (IRIB) was interrupted when an Israeli strike hit its Tehran building on Monday.
Prior to the strike, Defence Minister Israel Katz said that Iran’s “propaganda and incitement megaphone is about to disappear”.
Iran later “issued an evacuation warning for the N12 and N14 channels of Israel”, state TV reported, calling the order a “response to the hostile attack” on IRIB.
“I have four children, four boys. We’re very scared, but everyone is OK,“ said Idan Bar, whose building in Petah Tikva was among those hit.
The aircraft carrier USS Nimitz was also leaving Southeast Asia on Monday after cancelling plans to dock in Vietnam, amid reports it was headed to the Middle East to boost the US presence there.
International calls for calm have mounted.
French President Emmanuel Macron called for both sides to “end” strikes on civilians and warned that aiming to overthrow Tehran’s clerical state would be a “strategic error”.
Trump had initially urged Iran to come back to the negotiating table, but then wrote on his Truth Social platform: “Everyone should immediately evacuate Tehran!”
The United States and Iran had engaged in several rounds of indirect talks on Tehran’s nuclear programme in recent weeks, but Iran said after the start of Israel’s campaign that it would not negotiate while under attack.
“It takes one phone call from Washington to muzzle someone like Netanyahu. That may pave the way for a return to diplomacy,“ he wrote on X.
But Netanyahu did not rule out the possibility when asked about the reports during an interview with ABC News.
“It’s not going to escalate the conflict, it’s going to end the conflict,“ he said.
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