It was not immediately clear who was behind the attacks, but guerrillas who broke away from the once-powerful FARC rebel army are known to operate in that part of Colombia.
The National Police chief, Carlos Fernando Triana, told La FM radio that assailants had attacked targets with car bombs, motorcycle bombs, rifle fire and a suspected drone.
Police later said at least two civilians were among those killed, and 12 others were injured.
Corinto resident Luz Amparo was at home when the blast also gutted her bakery.
Her phone began to ring of the hook, and she went to her check on her store. As she rounded the corner the neighbors began to look in her direction.
Triana suggested the attacks may be linked to the third anniversary of the killing of FARC dissident leader Leider Johani Noscue, better known as “Mayimbu.”
Conservative senator Miguel Uribe, 39, was shot twice in the head at close range by a 15-year-old alleged hitman while campaigning Saturday.
Thousands have taken to the streets in major cities to light candles, pray and voice their anger at the assassination attempt.
Many Colombians are fearful of a return to the violence of the 1980s and 1990s, when cartel attacks, guerrilla violence and political assassinations were commonplace.
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