Last week, Sheinbaum's US counterpart Donald Trump agreed to offer another month of temporary relief on threatened tariffs on imports from Mexico.
But she also warned Mexico “cannot give up our sovereignty.”
But on Thursday, Trump once again put a pause on plans to impose a 25 percent tariff on imports into the United States from Mexico -- which represent 80 percent of Mexican exports.
US financial markets had also reacted negatively to the tariff threat, and most economists agree that if implemented they would damage both countries' economies.
In the Mexican capital’s Zocalo square, she added: “We cannot yield on our sovereignty, nor can our people be affected by decisions made by foreign governments.
Trump's justification for tariffs on US imports from Mexico and Canada -- which are part of the USMCA trilateral free trade deal -- has varied.
He claims the US economy is losing out to unfair Mexican and Canadian competition, but also accused both of turning a blind eye to undocumented migrants and illegal drugs.
Citing US figures, Shenbaum told the crowd that -- thanks to seizures made in Mexico -- the amount of fentanyl into the United States across the countries' 1,900-mile (3,100-kilometer) border decreased by half between October 2024 and January 2025.
While Mexico is an important supplier to the United States of products such as avocados and tequila, the biggest impact of a trade war would be on the manufacturing production chains of the three USMCA partners.
Seeking to correct alleged trade imbalances, Trump has pledged to launch “reciprocal” tariffs on all countries beginning on April 2.
Sheinbaum said she was “optimistic because on that day... they would not have to be applied” to Mexico, given most products are covered by the USMCA trade deal.
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