At the 97th Academy Awards, Moore was considered the frontrunner in the race for Best Actress for her critically acclaimed performance as Elizabeth Sparkle in The Substance. The film marked a significant comeback for Moore at a time when she was ready to give up Hollywood, which is notorious for its ageist attitude towards female actresses. Then, The Substance script arrived on her desk and would become one of the biggest horror films of the year. In the film, Moore portrays Sparkle, a former Academy Award winner who takes an experimental substance to create a younger, “better” version of herself after being fired from her job on her 50th birthday. It marked a career-best performance for Moore, who perfectly reflected the female experience in her vulnerable, brutal role.
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