Imagine that, in the past decade, many young people developed a serious illness — one that had previously been rare. Let’s say there’s no consensus about how to diagnose or treat it, nor any way to discern who would grow out of it naturally or for whom it would be permanent. Still, some parents and providers passionately support a specific, highly invasive medication. So does an advocacy group that creates the guidelines most Americans follow. That group engages an evidence-based medicine center at an esteemed university to conduct systematic reviews — the highest method of evaluating evidence, which tells us if the findings can be trusted and mapped onto the larger population.
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