Introduction The increasing prevalence of multidrug-resistant (MDR) gram negative bacteria (GNB) worldwide poses a great threat to anti-infection treatment.1,2 The vast majority of MDR-GNB production is caused by β-lactamases, which prevents antibiotics from exerting their effects.3–6 Avibactam has inhibitory effects on the vast majority of β-lactamases and carbapenemases, especially KPC.7–9 Ceftazidime/avibactam has been used to treat complex abdominal infections, hospital acquired pneumonia, ventilator-associated pneumonia, and infections caused by carbapenem resistant Enterobacteriaceae and Pseudomonas aeruginosa in adult patients with limited treatment options.10,11 It has demonstrated
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