Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses ...Middle East

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In a recent study published in the journal PLOS Biology, researchers in France investigated the cellular function and antiviral role of human SAMD9L and its paralog SAMD9 (short for sterile alpha motif domain-containing proteins 9 and 9-like) in HIV-1 (short for human immunodeficiency virus 1) restriction. They found that interferon (IFN)-stimulated human SAMD9L inhibits HIV-1 and primate lentiviruses in late replication phases, impacting viral translation and endosomal trafficking, while paralog SAMD9 enhances HIV-1 replication. Study: SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation. Image Credit: NIAID Background SAM

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