More important than the speed of bringing artificial intelligence (AI) into widespread use in American health care, is ensuring we do it correctly. To unlock the innovation’s greatest positive impact, assurance of integrity and transparency must take the highest priority. This can be accomplished by applying the principles that guide clinical research, including the respect for the human person, maximization of benefits and avoidance of harms to patients, just distribution of benefits, meaningful informed consent and protection of patient confidential information. The emergence of artificial intelligence is reminiscent of the great Gold Rush, a frenzied time bursting with unlimited po
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