Letby, 33, denies murdering seven babies at the Countess of Chester Hospital neonatal unit and attempting to murder 10 more.
After several months of hearing evidence, jurors had retired to consider verdicts on Monday, July 10.
The 22 charges are seven of murder, and 15 of attempted murder, which the prosecution allege happened at the neonatal unit between June 2015 and June 2016.
Last week the jury was reduced to 11 when a female juror was discharged for personal reasons.
The trial judge’s direction came on the 15th day of the jury’s deliberations which have so far lasted more than 76 hours.
Manchester Crown Court, Mr Justice Goss said: “I am going to ask you to return to your deliberating room and continue with your deliberations and strive to reach unanimous verdicts.
The judge in the trial of nurse Lucy Letby has ruled that jurors can return majority verdicts.
Countess of Chester Hospital between June 2015 and June 2016.
Following nine months of evidence, a jury of seven women and four men have been deliberating for 15 days.
Over the course of the trial, they heard claims that Ms Letby had deliberately injected babies with air, injected some with insulin and overfed others with milk.
Ms Letby, from Hereford, denies all the charges.
Addressing the jury at Manchester Crown Court, Mr Justice Goss said: “I am going to ask you to return to your deliberating room and continue with your deliberations and strive to reach unanimous verdicts.
“However, the time has now come when it is possible for me to accept verdicts upon which you are not all agreed, commonly referred to as majority verdicts.
“It must be by a majority of at least 10 of you, either 11-0 or 10-1.
The judge told the 11 jurors that he would now accept a majority verdict from them. That means if 10 out of the 11 jurors agree on a verdict, that will now be accepted. Previously, the jury had to be unanimous on all counts.
The judge told the jurors they should still strive to reach a unanimous verdict, but a verdict of 10-1 would be acceptable. He added: "Nothing else will do" in relation to verdicts.
The jury of seven women and four men has been deliberating for about 77 hours.
The Standard will continue to provide news on any developments from court.
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